ACAN polyclonal antibody
产品名称： ACAN polyclonal antibody
英文名称： ACAN polyclonal antibody
产品编号： PAB18067
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACAN .
- Immunogen:
- A synthetic peptide corresponding to amino acids 336-369 of human ACAN.
- Sequence:
- FFGVGGEED
- Host:
- Rabbit
- Reactivity:
- Human, Rat
- Specificity:
- This antibody is specific to endogenous levels of fragment of activated ACAN resulting from cleavage adjacent to Asp369.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500~1:1000)
Immunohistochemistry (1:50~1:100)
ELISA(1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets.
Matthews RT, Kelly GM, Zerillo CA, Gray G, Tiemeyer M, Hockfield S.J Neurosci. 2002 Sep 1;22(17):7536-47.
- 2.
- SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.
Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M.J Biol Chem. 2000 Apr 14;275(15):10738-44.
- 3.
- Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells.
Liu Y, Watanabe H, Nifuji A, Yamada Y, Olson EN, Noda M.J Biol Chem. 1997 Nov 21;272(47):29880-5.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from Jurkat cells, treated with Etoposide (25 uM, 60 mins), using ACAN polyclonal antibody (Cat # PAB18067).
Peptide "+" means "with peptide blocking".
- Entrez GeneID:
- 176
- Protein Accession#:
- P16112
- Gene Name:
- ACAN
- Gene Alias:
- AGC1,AGCAN,CSPG1,CSPGCP,MSK16,SEDK
- Gene Description:
- aggrecan
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq
- Other Designations:
- aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122),aggrecan proteoglycan,cartilage-specific proteoglycan core protein,chondroitin sulfate proteoglycan 1,large aggregating proteo
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