MAP2K5 (phospho S142) Peptide
产品名称： MAP2K5 (phospho S142) Peptide
英文名称： MAP2K5 (phospho S142) Peptide
产品编号： P1495
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP2K5.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S142 of human MAP2K5.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.
Cameron SJ, Abe J, Malik S, Che W, Yang J.J Biol Chem. 2004 Jan 9;279(2):1506-12. Epub 2003 Oct 28.
- 2.
- MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE, Leung HY.Oncogene. 2003 Mar 6;22(9):1381-9.
- 3.
- Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray.
Weldon CB, Scandurro AB, Rolfe KW, Clayton JL, Elliott S, Butler NN, Melnik LI, Alam J, McLachlan JA, Jaffe BM, Beckman BS, Burow ME.Surgery. 2002 Aug;132(2):293-301.
- Applications
- Dot Blot (Peptide)
- Dot blot analysis of MAP2K5 (phospho S142) polyclonal antibody (Cat # PAB0512) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 ug/mL. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
- Entrez GeneID:
- 5607
- Protein Accession#:
- NP_002748;Q13163
- Gene Name:
- MAP2K5
- Gene Alias:
- HsT17454,MAPKK5,MEK5,PRKMK5
- Gene Description:
- mitogen-activated protein kinase kinase 5
- Omim ID:
- 602520
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- MAP kinase kinase MEK5b,MAPK/ERK kinase 5,dual specificity mitogen-activated protein kinase kinase 5